Table 1.

Mean ± SE tumor volume by treatment group and by time point for the established tumor models

FaDu xenograftsDay 0Day 7Day 12Day 14Day 20
Control37.5 ± 7.5500.9 ± 104.71,444.9 ± 294.0*1,316.0 ± 258.71,622.31 ± 397.8
Cisplatin38.6 ± 6.1302.3 ± 120.9896.4 ± 270.1*879.2 ± 272.6883.9 ± 353.5
CCI-77941.8 ± 7.5107.3 ± 25.2478.5 ± 65.4508.1 ± 69.9650.6 ± 80.0
Cisplatin + CCI-77940.7 ± 7.9188.8 ± 88.1340.0 ± 106.2522.5 ± 157.3511.7 ± 163.1
XRT39.0 ± 6.2196.0 ± 40.0467.1 ± 93.5683.4 ± 158.7844.4 ± 157.2
Cisplatin + XRT39.9 ± 7.9249.1 ± 104.9386.5 ± 149.0465.9 ± 192.2550.2 ± 218.1
CCI-779 + XRT40.5 ± 11.293.1 ± 36.4132.7 ± 36.5130.1 ± 41.3209.4 ± 55.5
Cisplatin + CCI-779 + XRT39.8 ± 10.2162.7 ± 73.6198.2 ± 76.7243.6 ± 110.9218.5 ± 73.5
SCC40 xenograftsDay 0Day 7Day 14Day 17Day 20
Control37.2 ± 8.0172.1 ± 45.0722.2 ± 252.2911.3 ± 323.7*1,034.2 ± 340.93
Cisplatin37.3 ± 11.5233.6 ± 70.2745.0 ± 266.1952.7 ± 295.9*1,136.2 ± 274.2
CCI-77937.4 ± 7.5101.0 ± 35.1166.9 ± 95.3202.4 ± 119.6267.4 ± 161.2
Cisplatin + CCI-77937.2 ± 8.861.9 ± 15.5115.3 ± 56.377.7 ± 39.386.0 ± 52.1
XRT37.3 ± 7.7124.5 ± 15.6294.9 ± 54.7373.4 ± 72.7583.1 ± 149.1
Cisplatin + XRT37.2 ± 8.1120.0 ± 17.4199.6 ± 52.4252.0 ± 77.3340.0 ± 89.8
CCI-779 + XRT37.4 ± 11.480.1 ± 17.181.6 ± 22.586.4 ± 21.458.5 ± 11.1
Cisplatin + CCI-779 + XRT37.3 ± 11.847.8 ± 9.949.4 ± 10.878.8 ± 37.049.5 ± 11.9
  • *The last day when all mice in the group were alive.