Table 1.

Structure and inhibition potency against the murine and human soluble epoxide hydrolases

InhibitorsNameInhibition of the murine sEHInhibition of the human sEH
StructureIC50 (nmol/L)IC50 (nmol/L)KI (nmol/L)
Sorafenib30 ± 312 ± 217 ± 4
Sunitinib17,000 ± 1,00055,000 ± 1,000ND
Dasatinib27,000 ± 2,0006,500 ± 500ND
AUDA8 ± 13 ± 16.9 ± 0.2
t-AUCB4 ± 12 ± 11.5 ± 0.2
TPAU44 ± 312 ± 357 ± 6
TUPS11 ± 13 ± 114 ± 4

Abbreviations: ND, not determined; sEH, soluble epoxide hydrolase.