EGFR mutation patterns and clinicopathologic features of studied cases
| No. | Sex | Age | SS | Histology | Df | T size (cm) | T stage | N stage | M stage | Path stage | EGFR | KRAS | Exon | Nucleotide alteration | AA change | Exon | Nucleotide alteration | AA change | Remarks |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E109 | M | 53 | Ex | AD | WD | 3 | 1 | 0 | 0 | 1A | Q787R+L858R | WT | 20 | 2,606A>G | Q787R | 21 | 2,819T>G | L858R | Novel |
| E120 | F | 63 | NS | AD | MD | 2.5 | 1 | 0 | 0 | 1A | E709A+G719C | WT | 18 | 2,372A>C | E709A | 18 | 2,401G>T | G719C | Novel |
| E297 | F | 71 | PS | AD | WD | 3 | 1 | 0 | 0 | 1A | T790M+L858R | WT | 20 | 2,615C>T | T790M | 21 | 2,819T>G | L858R | |
| E1283 | M | 56 | SM | AD | NA | NA | 4 | 3 | 1 | 4 | H870R+L858R | WT | 21 | 2,819T>G | L858R | 21 | 2,855A>G | H870R |
Abbreviations: F, female; M, male; SS, smoking status as defined in the previous study (8); Ex, exsmoker; NS, nonsmoker; PS, passive smoker; SM, current smoker; AD, adenocarcinoma; Df, differentiation; WD, well differentiated; MD, moderately differentiated; T, tumor; N, lymph node; M, metastasis; Path stage, pathologic stage; AA, amino acid; NA, not available.