Table 2.

Average IC50 values in μmol/L for AZD5438-mediated growth inhibition in a broad range of human tumor cell lines in vitro

Cell lineDescriptionAverage IC50 (μmol/L)SDn
MCF-7Breast0.220.1012
MCF-7AdRBreast0.31ND3
MDA-MB-231Breast0.460.065
HCT-116Colon0.320.087
HCT-15Colon1.130.223
HT29Colon1.050.728
LoVoColon0.630.2610
SW620Colon0.580.298
Colo-205Colon0.700.185
A549Lung0.570.083
NCI-H322Lung0.400.125
NCI-H460Lung0.870.196
PC-3Prostate0.200.074
DU145Prostate0.420.022
A2780Ovarian1.260.173
HeLaCervix1.100.302
IM-9Multiple myeloma1.00ND1
MOLP-8Multiple myeloma1.10ND1
AMO-1Plasmacytoma1.00ND1
ARH-77Plasma cell leukemia1.70ND1
KARPAS-620Plasma cell leukemia0.74ND1
JJN-3Plasma cell leukemia0.94ND1
L-363Plasma cell leukemia0.50ND1