Table 1.

Average IC50 values in μmol/L for AZD5438 activity against a panel of cdks in vitro

cdk2-cyclin Ecdk2-cyclin Acdk1-cyclin B1cdk4-cyclin D1cdk5-p25cdk6-cyclin D3cdk7-cyclin Hcdk9-cyclin T
AZD5438 IC50 (μmol/L)0.0060.0450.0160.4490.0140.0210.8210.020
n103632111
Flavopiridol IC50 (μmol/L)0.2820.4050.0270.132ND0.3950.5140.011
n6326111
R-roscovitine IC50 (μmol/L)0.2492.1220.669≥100.331≥300.5130.572
n33434111

Abbreviations: n, number of repeats; ND, not done.