Table 2.

Plasma pharmacokinetic parameters for NU3166 and NU3153 following either a single dose of NU3153 at 10 mg/kg i.p., NU3166 at 12 mg/kg i.p. or i.v., or 120 mg/kg i.p.

Drug and doseNU3153, 10 mg/kg i.p.NU3166, 12 mg/kg (≡10 mg/kg NU3153) i.p.NU3166, 12 mg/kg (≡10 mg/kg NU3153) i.v.NU3166, 120 mg/kg (≡100 mg/kg NU3153) i.p.
Compound detectedNU3153NU3166NU3153NU3166NU3153NU3166NU3153
AUC (μg/mL.min)33482378957285876,933
Clearance (mL/min/kg)4.8122271061417014
Half-life (min)1259971209584307634
Cmax (μmol/L)1.50.91.64.66.23.07.9
Tmax (min)12015905105240
Time above 1 μmol/L (min)>345<1,440n/a21015>240<360120>1,440
Vdss (L/kg)0.15113.56.21.4465.5