Inhibition of thymidine transport and incorporation in L1210 and COR-L23 cells
| Inhibition of | |||
|---|---|---|---|
| Thymidine transport (L1210) | Thymidine incorporation (L1210) | Thymidine incorporation (COR-L23) | |
| Dipyridamole, 1 μmol/L | 80 ± 8% | 96 ± 4% | 96 ± 1% |
| Dipyridamole IC50 | 126 ± 54 nmol/L | 15 ± 4 nmol/L | |
| NU3108, 1 μmol/L | 83 ± 8% | 88% | 90 ± 1% |
| NU3108 IC50 | 93 nmol/L | 26 ± 5 nmol/L | |
| NU3144, 1 μmol/L | 98 ± 6% | 97% | 94% |
| NU3144 IC50 | <10 nmol/L | 59 nmol/L | |
| NU3150, 1 μmol/L | 93 ± 8% | 100% | 96% |
| NU3150 IC50 | 36.4 nmol/L | 60 nmol/L | |
| NU3151, 1 μmol/L | 73 ± 6% | 100% | 93% |
| NU3151 IC50 | 41.4 nmol/L | 67 nmol/L | |
| NU3153, 1 μmol/L | 96 ± 12% | 93 ± 4% | 96 ± 2% |
| NU3153 IC50 | <10, 43, 8 nmol/L | 8 ± 1 nmol/L | |
NOTE: Data are the mean ± SD of three or more independent experiments or individual experiments. The IC50 is the concentration required to inhibit thymidine incorporation by 50% of control.