Table 1.

Inhibition of thymidine transport and incorporation in L1210 and COR-L23 cells

Inhibition of
Thymidine transport (L1210)Thymidine incorporation (L1210)Thymidine incorporation (COR-L23)
Dipyridamole, 1 μmol/L80 ± 8%96 ± 4%96 ± 1%
Dipyridamole IC50126 ± 54 nmol/L15 ± 4 nmol/L
NU3108, 1 μmol/L83 ± 8%88%90 ± 1%
NU3108 IC5093 nmol/L26 ± 5 nmol/L
NU3144, 1 μmol/L98 ± 6%97%94%
NU3144 IC50<10 nmol/L59 nmol/L
NU3150, 1 μmol/L93 ± 8%100%96%
NU3150 IC5036.4 nmol/L60 nmol/L
NU3151, 1 μmol/L73 ± 6%100%93%
NU3151 IC5041.4 nmol/L67 nmol/L
NU3153, 1 μmol/L96 ± 12%93 ± 4%96 ± 2%
NU3153 IC50<10, 43, 8 nmol/L8 ± 1 nmol/L

NOTE: Data are the mean ± SD of three or more independent experiments or individual experiments. The IC50 is the concentration required to inhibit thymidine incorporation by 50% of control.