Table 1.

Gene set enrichment analysis on the four most bosutinib-sensitive cases with high expression of CAV-1 versus four most resistant cases with low CAV-1

Top 10 pathways enriched in the sensitive cases, sorted by nominal P
NameKEGG PathwaySizeNESP
HSA03030DNA polymerase241.710.007
HSA00532Chondroitin sulfate biosynthesis181.750.011
HSA04510Focal adhesion1941.360.011
HSA04512ECM-receptor interaction851.430.012
HSA00790Folate biosynthesis371.470.024
HSA04060Cytokine-cytokine receptor interaction2471.300.027
HSA05222Small cell lung cancer861.330.028
HSA00760Nicotinate and nicotinamide metabolism391.440.034
HSA04916Melanogenesis1011.350.037
HSA01430Cell Communication1171.310.071
Top 10 pathways enriched in the resistant cases, sorted by nominal P
HSA03010Ribosome54−2.900.000
HSA00071Fatty acid metabolism50−1.950.000
HSA00340Histidine metabolism40−1.850.000
HSA00350Tyrosine metabolism55−1.720.000
HSA00650Butanoate metabolism44−1.590.005
HSA00591Linoleic acid metabolism35−1.670.009
HSA00565Ether lipid metabolism29−1.640.014
HSA00980Metabolism of xenobiotics by cytochrome P45060−1.390.022
HSA00360Phenylalanine metabolism29−1.530.023
HSA00960Alkaloid biosynthesis II19−1.540.026