Table 2.

Dose escalation scheme and treatment-emergent toxicities of ES-285

Dose level (mg/m2)No. of patients (cycles)Injection site reactionNausea/vomitingFatigueFeverTransaminitisCentral neurotoxicity
Grade 1–2Grade 3–4Grade 1–2Grade 3–4Grade 1–2Grade 3–4Grade 1–2Grade 3–4Grade 1–2Grade 3–4Grade 1–2Grade 3–4
44 (6)2 (2)
84 (13)2 (5)1 (5)
163 (10)1 (2)
324 (9)2 (2)
643 (8)2 (3)1 (2)
1283 (5)3 (5)1 (1)
2564 (12)1 (2)1 (2)1 (1)3 (4)2 (2)*1 (1)*
2003 (9)1 (1)1 (2)1 (1)1 (1)*

NOTE: The number of patients experiencing toxicity during cycle 1 is shown for each dose level. Total episodes of toxicity during all cycles of treatment are shown in parentheses.

  • *Dose-limiting toxicities.