Table 1.

Xenograft growth delay

XenograftGrowth delay (d)
HCT116 to 0.3 cm30.0
HCT116 + sunitinib4.0
HCT116HIF-1α-/-4.5
HCT116HIF-1α-/- + sunitinib7.5
HCT116HIF-2α-/-1.5
HCT116HIF-2α-/- + sunitinib18.0
HCT116HIF-1α-/-HIF-2α-/->30
HCT116HIF-1α-/-HIF-2α-/- + sunitinib>30*
HCT116VEGF-/->30
HCT116VEGF-/- + sunitinib>30
HCT15 to 0.25 cm30.0
HCT15 + sunitinib1.0
HCT15HIF-1α-/-10.0
HCT15HIF-1α-/- + sunitinib19.0
LOVO to 0.2 cm30.0
LOVO + sunitinib7.0
LOVOHIF-1α-/-5.0
LOVOHIF-1α-/- + sunitinib18.0

NOTE: Xenograft growth delay was calculated as days for sunitinib-treated or knockout xenograft to reach designated size compared with parental xenografts. The designated sizes are listed in the table and shown graphically in Figs. 2 and 4.

  • *Complete remission in 50% of mice.