Table 1.

CPT-11, SN-38, and SN-38G concentrations in EJ and EJ/mβG xenografts in Beige-SCID mice after i.v. administration of 10 mg/kg CPT-11

(Pro)drugTime (h)EJ (ng drug per g tumor)EJ/mβG (ng drug per g tumor)Difference (%)
CPT-1121,350 ± 2001,500 ± 23014.95
887 ± 1777 ± 178−10.92
240.58 ± 0.090.63 ± 0.11−8.6
SN-38243 ± 10.571 ± 1365.63*
87.5 ± 0.9317 ± 5.56127.10*
240.07 ± 0.020.12 ± 0.0171.43*
SN-38G2110 ± 2162 ± 17−43.92*
821 ± 5.013 ± 1.6−38.97*
240.32 ± 0.050.17 ± 0.01−46.87*

NOTE: Mean values ± SD of four measurements. Differences are calculated taking EJ values as 100%.

  • *Statistically significant difference of P <0.05.