Table 3.

Plasma stability, microsomal stability, and cell permeability of selected 5,5′ substituted Apogossypol derivatives

CompoundRPlasma stability (T = 1 h)Microsomal stability (T = 1 h)Cell permeability
ApogossypolEmbedded Image53%75%Low
BI79D7Embedded Image90%68%Medium
BI79D8Embedded Image79%27%Low
BI79D9Embedded Image62%52%Low
BI79D10Embedded Image85%64%Medium
BI79F4Embedded ImageND41%Low
BI79F7Embedded Image72%92%Medium
BI79D2Embedded Image90%30%Medium

Abbreviation: ND, not determined.