Table 2.

Cross-activity of selected 5,5′ substituted Apogossypol derivatives against Bcl-XL, Bcl-2, and Mcl-1

Embedded Image
CompoundREC50 (μmol/L) FPAKd (μmol/L) ITC
Bcl-XLBcl-2Mcl-1Bcl-XL
ApogossypolEmbedded Image3.692.802.601.70
BI79D10Embedded Image0.190.360.520.17
BI79F7Embedded Image0.320.781.100.04
BI79D9Embedded Image0.161.902.202.75