Table 2.

AT7519 induces apoptosis in human tumor cell lines

Cell lineTreatment time (h)% Control survival, IC50% Control survival, IC90
HCT116889 ± 945 ± 8
2452 ± 70 ± 0
A2780850 ± 218 ± 4
243 ± 10 ± 0
HT29894 ± 1266 ± 14
2494 ± 2323 ± 7
  • NOTE: The induction of apoptosis in several human tumor cell lines was assessed using a colony formation assay. Cell lines were plated out and exposed to compound at concentrations relating to the IC50 and IC90 for the indicated times. The number of colonies growing through following compound exposure were determined and compared to vehicle control. Data are the percentage of colonies observed in compound-treated wells compared with the numbers observed in vehicle control wells. Mean ± SD of three independent experiments.