Table 1.

Trial schema for a phase I trial of interleukin-12 in combination with paclitaxel plus trastuzumab in patients with HER2-positive malignancies, NCI protocol no. 84

Cycle I:
    Week 1:Day1234567
    TreatmentT/P
    Week 2:Day891011121314
    Treatmentt
    Week 3:Day15161718192021
    Treatmentt
Cycles II and up:
    Week 1:Day1234567
    Treatmentt/PCC
    Week 2:Day891011121314
    TreatmenttCC
    Week 3:Day15161718192021
    TreatmenttCC

NOTE: T, trastuzumab (4 mg/kg i.v.); t, trastuzumab (2 mg/kg i.v.); P, paclitaxel (175 mg/m2 × 3 h i.v.); C, IL-12 (100 or 300 ng/kg i.v. or 200 ng/kg s.c.).