Table 2.

Number of significant associations for each concentration of carboplatin

Approach% survival phenotypes
10 μmol/L20 μmol/L40 μmol/L80 μmol/LIC50 (μmol/L)
SNP associated with phenotype (P ≤ 0.0001)470 SNPs535 SNPs574 SNPs741 SNPs439 SNPs
SNP associated with gene expression (Bonferroni-corrected P < 0.05)58 SNPs (75 transcript clusters)75 SNPs (103 transcript clusters)66 SNPs (85 transcript clusters)132 SNPs (133 transcript clusters)65 SNPs (71 transcript clusters)
Gene expression correlated with phenotype (P < 0.05)33 Transcript clusters (39 SNPs)53 Transcript clusters (65 SNPs)37 Transcript clusters (41 SNPs)71 Transcript clusters (97 SNPs)38 Transcript clusters (46 SNPs)