Table 1.

Comparison of pharmacokinetic variables for single-dose and multiple-dose docetaxel in mice and humans

t1/2 (h)AUC0→24 (μmol/L h)Cmax (nmol/L)Cmin (nmol/L)Total dose delivered (nmol)
Single-dose pharmacokinetics
    Human 30 mg/m2*27.5 ± 5.51.02 ± 0.391342 ± 65563.6 ± 9.6 μmol
    Mouse 6 mg/kg i.p.11.51.23870139
    Mouse 1 mg/kg i.p.11.00.148023
Multiple-dose pharmacokinetics
    Mouse 6 mg/kg q4d12.58760.8975
    Mouse 1 mg/kg qd5.9841.4650
    Mouse 1 mg/kg (modified schedule)3.9840441
  • * Human plasma pharmacokinetic variables were calculated using a three-compartment models with i.v. infusion input of drug. Data from ref. 31.

  • Mouse single-dose plasma pharmacokinetic variables were calculated using noncompartmental analysis of simulated data.

  • AUC for multiple doses calculated in Microsoft Excel using trapezoidal rule.