Table 1.

Summary of pharmacokinetic PET variables for [¹⁸F]FLT obtained from the time versus radioactivity curves in vehicle-treated and PD0325901-treated tumor-bearing mice

	Vehicle, day 1	PD0325901 (25 mg/kg), day 1	Vehicle, day 10	PD0325901 (25 mg/kg), day 10
(A) SKMEL-28 tumor
NUV₆₀	1.52 ± 0.32	0.72 ± 0.23*	1.38 ± 0.26	0.93 ± 0.1^†
NUV_max	1.81 ± 0.18	1.23 ± 0.10^†	2.07 ± 0.40	1.08 ± 0.14^†
AUC	60.58 ± 9.46	38.76 ± 13.80*	72.43 ± 13.87	49.02 ± 13.72^†
FRT_1.5/60	3.27 ± 0.64	2.69 ± 1.01*	3.76 ± 0.87	2.52 ± 0.24^†

(B) HCT116 tumor
NUV₆₀	1.70 ± 0.35	0.93 ± 0.19^†	1.73 ± 0.08	0.91 ± 0.1^†
NUV_max	2.30 ± 0.84	1.88 ± 0.36*	1.97 ± 0.13	1.00 ± 0.03^†
AUC	70.68 ± 16.65	51.11 ± 7.74^†	73.57 ± 3.79	40.21 ± 3.22^†
FRT_1.5/60	3.27 ± 0.74	2.72 ± 0.88	4.11 ± 2.04	3.25 ± 0.97

NOTE: Data are the mean ± SE (n = 4).
Abbreviations: NUV₆₀, normalized uptake value at 60 min. NUV_max, normalized uptake values determined from voxels with the highest radioactivity. AUC, area under the curve. FRT, fractional retention of [¹⁸F]radioactivity at 60 min relative to 1.5 min.
↵* Significantly different from vehicle (P = 0.045).
↵† Significantly different from vehicle (P = 0.03).