Table 1.

Summary of pharmacokinetic PET variables for [18F]FLT obtained from the time versus radioactivity curves in vehicle-treated and PD0325901-treated tumor-bearing mice

Vehicle, day 1PD0325901 (25 mg/kg), day 1Vehicle, day 10PD0325901 (25 mg/kg), day 10
(A) SKMEL-28 tumor
NUV601.52 ± 0.320.72 ± 0.23*1.38 ± 0.260.93 ± 0.1
NUVmax1.81 ± 0.181.23 ± 0.102.07 ± 0.401.08 ± 0.14
AUC60.58 ± 9.4638.76 ± 13.80*72.43 ± 13.8749.02 ± 13.72
FRT1.5/603.27 ± 0.642.69 ± 1.01*3.76 ± 0.872.52 ± 0.24
(B) HCT116 tumor
NUV601.70 ± 0.350.93 ± 0.191.73 ± 0.080.91 ± 0.1
NUVmax2.30 ± 0.841.88 ± 0.36*1.97 ± 0.131.00 ± 0.03
AUC70.68 ± 16.6551.11 ± 7.7473.57 ± 3.7940.21 ± 3.22
FRT1.5/603.27 ± 0.742.72 ± 0.884.11 ± 2.043.25 ± 0.97
  • NOTE: Data are the mean ± SE (n = 4).

  • Abbreviations: NUV60, normalized uptake value at 60 min. NUVmax, normalized uptake values determined from voxels with the highest radioactivity. AUC, area under the curve. FRT, fractional retention of [18F]radioactivity at 60 min relative to 1.5 min.

  • * Significantly different from vehicle (P = 0.045).

  • Significantly different from vehicle (P = 0.03).