Table 1.

Molecular and biochemical features of breast cancer cell lines used in the study

MCF-7MBA-MD-157Hs578TMBA-MD-436HCC 1937UACC 3199 (*)
Tumor type*Human breast adenocarcinomaMedullary carcinomaInvasive ductal carcinomaHuman breast adenocarcinomaHuman breast carcinomaDuctal carcinoma
Molecular subtypesLuminalMesenchymalMesenchymalBasalBasal
TP53 statusWild-typeMutantMutantMutantMutant
ER+
Brca1 (allelic lost/mutation status)§Loss/wtLoss/ wtLoss/wtLoss/mutatedLoss/mutatedLoss/methylated
Effects after 17-AAG treatment
    IC50 (μmol/L)0.032 ± 0.00920.001480.057 ± 0.0210.059 ± 0.0170.014 ± 0.0060.013 ± 0.006
    Cell cycle effectG2-M arrestG2-M arrestG2-M arrestG2-M arrestG2-M arrestG2-M arrest
    SA-β-galactosidase stainingNoneNoneNoneNoneNoneNone
    Mitotic entranceLowNoneLowHighHighHigh
    Predominant cell deathApoptosisApoptosisApoptosisMitotic catastropheMitotic catastropheMitotic catastrophe
  • * Data derived from the American Type Culture Collection.

  • From ref. 29.

  • From ref. 30.

  • § From ref. 31.