Table 1.

Transcripts induced by elesclomol in Hs294T cells by elesclomol

Gene ID*Gene symbolGene titleFold changeFunctional category
3310HSPA6Heat shock 70 kDa421.3Chaperone
3310HSPA6Heat shock 70 kDa317.9Chaperone
90637ZFAND2AZinc finger, AN1-type domain18.3Metal binding
3304HSPA1BHeat shock 70 kDa13.8Chaperone
3337DNAJB1DNAJ (Hsp40) homologue, member 18.7Chaperone
3337DNAJB1DNAJ (Hsp40) homologue, member 17.8Chaperone
51278IER5Immediate-early response gene6.7Stress response
9531BAG3BCL2-associated anthogene5.7Chaperone related
3303HSPA1AHeat shock 70 kDa5.3Chaperone
4494MT1FMetallothionein 1F (functional)5.2Metal binding/antioxidant
6303SATSpermidine/spermine N14.4Polyamine regulation
10808HSPH1Heat shock 105/110 kDa4.2Chaperone
1410CRYABCrystalline, αB4.0Chaperone
4494MT1FMetallothionein 1F (functional)3.9Metal binding/antioxidant
4501MT1XMetallothionein 1X3.8Metal binding/antioxidant
163859C1orf55Chromosome 1 ORF553.7Uncharacterized
4496MT1HMetallothionein 1H3.7Metal binding/antioxidant
4495MT1GMetallothionein 1G3.6Metal binding/antioxidant
3475IRFD1IFN-related developmental regulator 13.6Transcriptional regulation
9709HERPUD1Homocysteine inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member3.5Stress response
2717GLAGalactosidase α3.3Hydrolase/antioxidant
4493MT1EMetallothionein 1E (functional)3.3Metal binding/antioxidant
3576IL-8Interleukin-83.3Cytokine/stress response
26973CHORDC1Cysteine and histidine-rich domain–containing 13.2Metal binding
9821RB1CC1RB1-inducible coiled-coil 13.2Transcription/stress response
4189DNAJB9DNAJ (Hsp40) homologue, member 93.1Chaperone
79693YRDCyrdC domain containing (Escherichia coli)3.0Transport regulator
56829ZC3HAV1Zinc finger CCCH-type, antiviral 13.0Metal binding
4489MT1MMetallothionein 1M3.0Metal binding/antioxidant
23645PPP1R15AProtein phosphatase 1, regulatory (inhibitor) subunit 15A2.9Stress response
  • NOTE: Cells were treated with 100 nmol/L elesclomol for 6 h, and 266 transcripts were induced by elesclomol. The top 30 genes are shown. The complete data were deposited in the GEO database. The accession number is GSE11550 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE11550).

  • * http://www.ncbi.nlm.nih.gov/sites/entrez. Entries with identical National Center for Biotechnology Information gene IDs represent results from different probe sets interrogating the same transcript.

  • Level of transcript relative to that observed for DMSO-treated cells.