Table 2.

Validation of predictive performance of the nine genes by examining the SVM value in an independent set of nine NSCLC cell lines

Cell linesIC50 (TSA)IC50 (vorinostat)Predicted classTrue class (TSA)True class (vorinostat)
1LCI-sq0.192.14SensitiveHighly sensitiveHighly sensitive
2VMRC-LCD0.270.87SensitiveHighly sensitiveHighly sensitive
3Lu650.343.74SensitiveHighly sensitiveIntermediate sensitive
4LCOK0.523.66SensitiveHighly sensitiveIntermediate sensitive
5NCI-H16500.899.37SensitiveHighly sensitiveIntermediate sensitive
6LC1F1.264.82SensitiveIntermediate sensitiveIntermediate sensitive
7NCI-H19751.563.96SensitiveIntermediate sensitiveIntermediate sensitive
8NCI-H4410.778.30SensitiveHighly sensitiveIntermediate sensitive
9Calu-60.582.10SensitiveHighly sensitiveHighly sensitive
  • NOTE: Cell lines were classified as highly sensitive (IC50 ≤ 1 μmol/L), intermediate sensitive (1 μmol/L < IC50 ≤ 15 μmol/L), and resistant (IC50 < 15 μmol/L) to TSA. In relation to response to vorinostat, cell lines were classified as highly sensitive (IC50 ≤ 3 μmol/L), intermediate sensitive (3 μmol/L < IC50 ≤15 μmol/L), and resistant (IC50 < 15 μmol/L).