Table 1.

Toxicity of anti-IL-13Rα2(scFv)-PE38 after i.p. administration in nude mice

Dose* (μg/kg)IL-13Rα2(scFv)-PE38 clone 4IL-13Rα2(scFv)-PE38 clone 7IL-13-PE38
200 q.d. × 50/50/55/5
150 q.d. × 50/50/52/5
200 q.o.d. × 30/50/53/5
150 q.o.d. × 30/50/50/5
  • NOTE: Maximum tolerated dose is defined as no deaths during 3-week observation at a particular dose.

  • * q.d. × 5, once daily for 5 consecutive days; q.o.d. × 3, every other day for 3 d of treatment.

  • Each value represents number of deaths/total number of animals.