Table 2.

LG268 and CDDO-MA are more potent than erlotinib for preventing lung carcinogenesis in A/J mice injected with vinyl carbamate, 20 wk on diet

ControlLG268, 60 mg/kg dietLG268, 30 mg/kg dietErlotinib, 200 mg/kg dietErlotinib, 100 mg/kg dietMA, 800 mg/kg diet
Analysis of inflated lungs
    No. mice/group231212121216
    No. tumors/group35689144144145146
    No. tumors/mouse (% control)15.5 ± 1.0 (100)7.4 ± 1.0* (48)12 ± 0.6 (77)12.0 ± 1.1 (77)12 ± 0.9 (78)9.1 ± 0.7* (59)
    No. tumors ≤0.5 mm (% of total tumors)14 (4)25 (28)*18 (13)19 (13)7 (5)63 (43)*
    No. tumors >1 mm (% of total tumors)103 (29)6 (7)*19 (13)10 (7)*30 (21)1 (1)*
Analysis of histopathology
    Total no. tumors/group1843378768373
    Average no. tumors/slide (% control)4.2 ± 0.3 (100)1.4 ± 0.3* (33)3.3 ± 0.4 (78)3.2 ± 0.3 (76)3.5 ± 0.3 (83)2.3 ± 0.3* (55)
    TTV, mm3559.245.3134.4131.4196.052.5
    Average tumor size, mm3 (% control)3.0 ± 0.3 (100)1.4 ± 0.4* (45)1.7 ± 0.4* (57)1.7 ± 0.4* (57)2.4 ± 0.5 (78)0.7 ± 0.1* (24)
    Average tumor burden, mm3/slide (% control)12.7 ± 1.5 (100)1.9 ± 0.4* (15)5.6 ± 1.2* (44)5.5 ± 1.0* (43)8.2 ± 1.0 (64)1.6 ± 0.3* (13)
    No. low-grade tumors (%)25 (13)3 (9)18 (23)23 (30)*14 (17)35 (48)*
    No. medium-grade tumors (%)51 (28)20 (61)*27 (35)30 (40)27 (32)20 (27)
    No. high-grade tumors (%)108 (59)10 (30)*33 (42)*23 (30)*42 (51)18 (25)*
  • NOTE: Female A/J mice were injected i.p. with two doses of vinyl carbamate (0.32 mg/mouse), 1 wk apart. One week after the final injection with the carcinogen, mice were fed compounds in diet for 20 wk. Mean ± SE.

  • * P < 0.05 versus control.