Table 1.

LG268 and erlotinib prevent lung carcinogenesis in A/J mice injected with vinyl carbamate, 14 wk on diet

ControlLG268, 60 mg/kg dietLG268, 30 mg/kg dietErlotinib, 200 mg/kg dietErlotinib, 100 mg/kg diet
Analysis of inflated lungs
    No. mice/group168888
    No. tumors/group252597088104
    No. tumors/mouse (% control)15.8 ± 1.0 (100)7.4 ± 1.3* (47)8.8 ± 1.1* (56)11.0 ± 1.8 (70)13.0 ± 1.5 (82)
    No. tumors ≤0.5 mm (% of total tumors)7 (3)13 (22)10 (14)16 (18)10 (10)
    No. tumors >1 mm (% of total tumors)49 (19)4 (7)2 (3)2 (2)11 (10)
Analysis of histopathology
    Total no. tumors/group12043435355
    Average no. tumors/slide (% control)3.9 ± 0.3 (100)2.9 ± 0.5 (74)2.7 ± 0.3 (69)3.3 ± 0.4 (85)3.4 ± 0.3 (89)
    TTV, mm325037.538.044.561.6
    Average tumor size, mm3 (% control)2.1 ± 0.3 (100)0.9 ± 0.2 (42)0.9 ± 0.2 (42)0.8 ± 0.1 (40)1.1 ± 0.1 (54)
    Average tumor burden, mm3/slide (% control)8.1 ± 1.5 (100)2.5 ± 0.6 (31)2.4 ± 0.5 (29)2.8 ± 0.6 (34)3.9 ± 0.6 (48)
    Total no. low-grade tumors (%)20 (17)22 (51)*20 (46)*17 (32)13 (23)
    Total no. medium-grade tumors (%)25 (21)9 (21)12 (28)16 (30)24 (44)
    Total no. high-grade tumors (%)75 (62)12 (28)*11 (26)*20 (38)18 (33)*
  • NOTE: Female A/J mice were injected i.p. with two doses of vinyl carbamate (0.32 mg/mouse), 1 wk apart. One week after the final injection with the carcinogen, mice were fed compounds in diet for 14 wk. Mean ± SE.

  • * P < 0.001 versus control.

  • P < 0.05 versus control.