Table 2.

Genotype distribution

GeneGenotypeEAAAAlleleEAAAP
ERCC1* N118N (500C>T)CC23 (0.21)96 (0.76)C99 (0.46)219 (0.86)
CT53 (0.49)27 (0.21)T117 (0.54)35 (0.14)
TT32 (0.30)4 (0.03)
Total108127Total216254<0.000001
ERCC1 C8092ACC77 (0.53)74 (0.52)C213 (0.73)204 (0.72)
AC59 (0.40)56 (0.40)A79 (0.27)78 (0.28)
AA10 (0.07)11 (0.08)
Total146141Total2922820.870913
ERCC2 K751Q (2282A>C)AA49 (0.42)81 (0.56)A154 (0.65)219 (0.76)
AC56 (0.47)57 (0.40)C82 (0.35)69 (0.24)
CC13 (0.11)6 (0.04)
Total118144Total2362880.006675
XRCC1 R399Q (1301G>A)GG49 (0.46)113 (0.80)G145 (0.68)252 (0.89)
AG47 (0.44)26 (0.19)A67 (0.32)30 (0.11)
AA10 (0.10)2 (0.01)
Total106141212282<0.000001
XRCC1 R194W (685C>T)CC120 (0.87)133 (0.90)C257 (0.93)280 (0.95)
CT17 (0.12)14 (0.09)T19 (0.07)16 (0.05)
TT1 (0.01)1 (0.01)
Total138148Total2762960.460941
PARP1 V762A (2446T>C)TT80 (0.67)108 (0.91)T192 (0.81)227 (0.95)
CT32 (0.27)11 (0.09)C46 (0.19)11 (0.05)
CC7 (0.06)0 (0)
Total119119Total2382380.000001
  • P value is calculated by χ2 test with 1 df based on allelic frequency.

  • * Gene name, amino acid change and position, and nucleotide change and position.

  • Count (frequency).