Table 2.

Comparisons between experimental and predicted values for blood levels (%ID/g) and organ-to-blood ratios of antibody-bound effector at 3 h postinjection of cMORF effector in LS174T tumored mice having received one of three MORF-conjugated antibodies 48 h before injection of cMORF effector

(A) Blood level
B72.3MN14CC49
Experimental3.75 ± 0.992.26 ± 0.381.60 ± 0.09
Predicted2.27 ± 0.572.51 ± 0.632.41 ± 0.60
(B) Organ-to-blood ratios

Predicted*
B72.3
MN14
CC49
Liver/blood0.310.30 ± 0.080.26 ± 0.030.23 ± 0.05
Spleen/blood0.150.16 ± 0.020.12 ± 0.020.15 ± 0.04
Lung/blood0.400.34 ± 0.060.33 ± 0.050.36 ± 0.04
Heart/blood0.200.21 ± 0.010.22 ± 0.000.15 ± 0.03
Muscle/blood0.110.11 ± 0.020.14 ± 0.090.10 ± 0.02
  • NOTE: Values presented as the average with 1 SD (n = 4).

  • * Taken from (17).