Table 1.

In vitro kinase assay

KinaseReversine
0.5 μmol/L1 μmol/L
Aurora A2012
Aurora B2513
Aurora C5520
CDK1/cyclin B9589
CDK2/cyclin A9478
CDK2/cyclin E8778
CDK3/cyclin E8684
CDK6/cyclin D39181
CDK7/cyclin H/MAT18480
CDK9/cyclin T18369
CHK18870
GSK3α9591
GSK3β102108
MAPK1106109
MAPK210691
MEK18369
PDK17562
PKA7647
PKBα120127
PKBβ10296
PKBγ9694
PKCβII9397
PKCδ8083
Plk3113112
SAPK2a9293
SAPK2b9392
  • NOTE: The Table shows the activity (expressed as a percentage) of a panel of protein kinases tested with an in vitro assay using 0.5 and 1 μmol/L of reversine.