Table 6.

KD5170 and docetaxel combination results in an increase in number of tumor regressions

Compound 1Compound 2Regressions
PRCRTFS
No treatment000
Vehicle 1Vehicle 2000
KD5170 30 mg/kg qod × 14000
Docetaxel 10 mg/kg qwk × 3111
Docetaxel 30 mg/kg qwk × 3230
KD5170 30 mg/kg qod × 14Docetaxel 10 mg/kg qwk × 3410
  • NOTE: Partial regression is when the tumor volume was 50% or less than that of day 1 for three consecutive measurements during the course of study and ≥13.5 mm3 for one or more of these three measurements. Complete regression is when the tumor volume was <13.5 mm3 for three consecutive measurements during course of study. An animal with a complete remission at termination of study is classified as a tumor-free survivor.

  • Abbreviations: PR, partial regression; CR, complete regression; TFS, tumor-free survivor.