Table 4.

KD5170 inhibits tumor growth in a human prostate cancer PC-3 xenograft

Compound 1Compound 2T/CBodyweight nadir (d)
No treatment0
Vehicle 1Vehicle 20
KD5170 30 mg/kg qod × 1432%0
Docetaxel 10 mg/kg qwk × 39%0
Docetaxel 30 mg/kg qwk × 3−4%−5.7% (d23)
KD5170 30 mg/kg qod × 14Docetaxel 10 mg/kg qwk × 3−11%6.5% (d20)
  • NOTE: T/C values at day 30 measurement point. Bodyweight nadir and day on which it was observed. A T/C value of 0 equals tumor stasis.