Table 1.

Protein markers of kinase inhibitor sensitivity

Protein endpointCorrelation coefficientPLower CIUpper CI
MEKi sensitivitypPyk2 Y402−0.60040.0005−0.7898−0.3063
pER S1180.47600.00780.13970.7139
EGFR−0.47150.0085−0.7110−0.1340
pc-Abl T735−0.46550.0095−0.7072−0.1265
pCofilin S30.46210.01010.12220.7050
pPKC a S657−0.44840.0130−0.6962−0.1051
pp27 T187−0.40610.0260−0.6685−0.0536
pATF-2 T710.39860.02910.04470.6636
pErk1-2 T202 Y204−0.38170.0374−0.6523−0.0249
pEGFR Y9920.37820.03930.02070.6499
PEGFR Y10680.37640.04040.01860.6487
pPDK1 S2410.37580.04070.01800.6483
pStat Y7010.36940.04460.01050.6440
pA-Raf S2990.36200.04930.00190.6389
pp70S6Kinase S3710.35590.0536−0.00500.6348
pc-Kit Y7210.35560.0538−0.00540.6346
PI3Ki-mTOR sensitivitypPRAS40 T246−0.49640.0053−0.7267−0.1658
pFKHRT24-FKHRL1 T32−0.49270.0057−0.7244−0.1610
pHistone H3 S10−0.37870.0390−0.6503−0.0214
pAkt T308−0.37850.0391−0.6501−0.0211
pStat3 Y705−0.37550.0409−0.6481−0.0176
pAkt S473−0.35180.0566−0.63200.0097
  • Abbreviation: CI, confidence interval.