Table 1.

Correlation between tumor growth rate and CED volume

Treatment*Initial tumor volume (cm3)Correlation between growth rate and CED volume
Salirasib20.27 ± 10.38r2 = 0.989; P < 0.0005
Control19.09 ± 7.02r2 = 0.189; P < 0.21
Salirasib51.59 ± 45.51r2 = 0.745; P < 0.1369
Control25.42 ± 12.60r2 = 0.0078; P < 0.868
Salirasib66.37 ± 51.10r2 = 0.578; P < 0.017
Control50.25 ± 68.81r2 = 0.11; P < 0.42
  • NOTE: The correlation between tumor growth rate and CED volume is presented for three experiments. Growth rates correspond to the ratios of the tumor volumes at the second follow-up and the tumor volumes at the first follow-up for each animal (n = 5-8). These values were correlated with the CED volume of the corresponding animal using Pearson's correlation test. The r2 values thus obtained are shown. P values indicate the statistical significance of the correlation. It can be seen that tumor growth rate is significantly affected by CED volume in the salirasib-treated rats and that this effect is larger for initially small tumors. The differences between initial tumor volumes of the groups reflect experimental variations among the randomly designated animals in each group.

  • * Treatment: 50 μmol/L salirasib or control vehicle.

  • Initial tumor volume: calculated from the MRI (average ± SD).