Table 1.

Correlation between XPA protein expression and drug activity in the ovarian and colon cell lines from the NCI-60 cell screen

NSC numberDrug nameXPA versus log10(GI50)
79037Lomustine (CCNU)−0.77
409962Carmustine (BCNU)−0.60
353451Mitozolamide−0.66
122819Teniposide−0.03
109229l-Asparaginase−0.03
32065Hydroxyurea0.03
752Thioguanine0.26
125973Taxol (Paclitaxel)0.26
  • NOTE: Pearson correlation was calculated between the negative log10(GI50) and XPA protein expression (21).

  • Abbreviations: CCNU, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea; BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea.