Table 2.

Inhibitory effects of CCN, colchicine, thiocolchicine, and combretastatin A-4 on tubulin assembly and on binding of [3H]colchicine to tubulin

CompoundInhibition of tubulin assembly IC50 (μmol/L), mean ± SDInhibition of [3H]colchicine binding (%), mean ± SD
Colchicine-cyanonilutamide1.1 ± 0.164 ± 1
Thiocolchicine1.0 ± 0.167 ± 0.07
Colchicine2.2 ± 0.4
Combretastatin A-41.3 ± 0.0898 ± 0.6