Table 3.

Colonic crypt length and mitotic count per crypt as radiotherapy progressed

Treatment groupCrypt length (μm)Mitoses (per crypt)
Week 1103.6 ± 11.5*0.9 ± 0.9
Week 2146.5 ± 8.1*0.6 ± 0.5
Week 3136.2 ± 18.1*0.7 ± 0.7
Week 4141.8 ± 11.9*0.4 ± 0.6
Week 5148.8 ± 15.4*0.9 ± 0.7
Week 6119.9 ± 14.50.5 ± 0.6
Untreated controls116.1 ± 15.4*1.7 ± 0.9
  • NOTE: Data are given as mean ± SD (μm). Crypt length was significantly increased when compared with the untreated controls, and mitotic count severely decreased throughout the 6-week radiation therapy.

  • * From week 1 to week 5, all P values were <0.001 when compared with controls.

  • From week 1 to week 6, all P values were <0.001 when compared with controls.