Table 2.

Villus height and crypt length and mitotic count per crypt as radiation treatment progressed

Treatment groupVillus height (μm)Crypt length (μm)Mitoses (per crypt)
Week 150.8 ± 8.960.8 ± 8.3*1.4 ± 1.0*
Week 256.8 ± 5.755.5 ± 7.4*1.2 ± 0.9*
Week 348.6 ± 9.471.0 ± 9.2*0.6 ± 0.7*
Week 443.7 ± 11.363.6 ± 8.8*0.5 ± 0.7*
Week 555.9 ± 8.559.3 ± 8.7*0.7 ± 0.6*
Week 651.7 ± 8.367.2 ± 9.7*0.8 ± 0.8*
Untreated controls52.5 ± 9.046.6 ± 7.1*2.7 ± 1.1*
  • NOTE: Data are given as mean ± SD (μm). Villus height was significantly decreased at weeks 3 and 4. Crypt length was significantly increased, whereas mitotic count was depleted throughout the duration of treatment.

  • * From week 1 to week 6, all P values were <0.001 when compared with untreated controls.

  • Week 3, P < 0.025; week 4, P < 0.001.