Table 3.

Urinary levels of polyphenols and their metabolites

Groups(−)-Epigallocatechin(−)-EpicatechinM4*M6*
Vehicle only0.21 ± 0.05 (0.7 μmol/L)1.5 ± 1.4 (6.1 μmol/L)0.14 ± 0.22 (0.1 μmol/L)4.0 ± 2.5 (2.6 μmol/L)
Polyphenon E, 250 mg/kg BW/d (8 h)21.8 ± 2.7 (70 μmol/L)26.8 ± 1.0 (94 μmol/L)3.68 ± 2.0 (2.2 μmol/L)32.6 ± 9.3 (20 μmol/L)
Polyphenon E, 250 mg/kg BW/d (16 h)18.8 ± 3.7 (62 μmol/L)26.5 ± 0.4 (93 μmol/L)4.5 ± 1.8 (2.6 μmol/L)41.5 ± 13 (27 μmol/L)
  • * M4, 5-(3′,4′,5′-trihydroxyphenyl)-γ-valerolactone; M6, 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone.

  • Values are μg/mL (and μmol/L) and are the mean ± SD obtained at termination of the study from rats not receiving the carcinogen.