Table 1.

Combination indices calculated for dose-response curves for combination studies described in results and shown in Figs. 2 and 3

Cell linesCombination indices
ED50ED76ED90
FLT3-ITD-Ba/F3 (LBW242 + PKC412)0.747800.588080.47158
A627T-Ba/F3 (LBW242 + PKC412)0555820.409460.36244
F691l-Ba/F3 (LBW242 + PKC412)0.634090.432670.30145
G697r-Ba/F3 (LBW242 + PKC412)0.397830.432100.47464
FLT3-ITD-Ba/F3 (LBW242 + doxorubicin)0.897230.812950.73688
A627T-Ba/F3 (LBW242 + doxorubicin)0.386130.356380.35964
FLT3-ITD-Ba/F3 (LBW242 + Ara-c)0.607840.451490.33535
F691l-Ba/F3 (LBW242 + Ara-c)0.603770.470240.41785