Table 2.

EpCAM (TROP1) and TROP2 expression by microarray and flow cytometry in a panel of HNSCC and NSCLC cell lines

Cell lineGefitinib sensitivityEpCAM (TROP1)
TROP2
Positive (%)MFIArrayPositive (%)MFIArray
HNSCC
    UM-SCC-2Sensitive100131751100175822
    HN4Sensitive100312305971815255
    UM-SCC-8Sensitive100427463971212344
    HN31Sensitive10012635210096977
    MDA 1586Sensitive100137531100212770
    UM-SCC-10AResistant0012004.3
    UM-SCC-22BResistant0018907.45474
    584Resistant0016753.21791
    1483Resistant001500660
NSCLC
    H322Sensitive1001058302943410421
    H358Sensitive100611002996218895
    Calu3Sensitive995773278647141
    H1648Sensitive1008557121004014348
    H157Resistant007004
    H520Resistant98567184004
    A549Resistant9817696004
    H1703Resistant0011004
    H460Resistant0022004