Table 1.

Effect of inhibiting Akt or mTOR on proliferation of pediatric cell lines

A443654 (% growth)Rapamycin (% growth)A443654 + rapamycin [% growth (additive)*]
Normoxia
    Rh-30425625 (25)
    Rh-36212311 (5)
    JR-107737 (0)
    NB-EB2410015 (24)
    NB-1691376434 (24)
    SK-N-SH715031 (35)
    SK-N-AS756161 (46)
Hypoxia
    Rh-30296115 (18)
    Rh-366273 (2)
    JR-10840 (0)
    NB-EB8796 (6)
    NB-16913610026 (36)
    SK-N-SH10010022 (100)
    SK-N-AS746037 (44)
  • * Additivity defined as the product of fractional growth for each agent (% growth rapamycin treated × % growth A443654 treated).