Table 2.

Growth characteristics of various melanoma xenografts treated with regional TMZ (2,000 mg/kg) and toxicity

Xenograft% Increase in tumor volume on day 30 (%, mean ± SE)Quintupling time (d, mean ± SE)Growth delay (d)Regression no. of ratsResponse CR/PR no. of rats% Maximal decrease in tumor size (%, mean ± SE)
DM440−23.62 ± 11.060.0 ± 0416/60/679.9 ± 2.4
DM443367.6 ± 39.730.1 ± 2.46.30/60/111.7 ± 12
DM366115.1 ± 46.454.9 ± 3.137.46/62/266.7 ± 15
DM6125.1 ± 87.347.3 ± 5.127.66/62/048 ± 17
DM738−27.22 ± 30.151.6 ± 4.330.66/63/391.6 ± 4.7