Table 1.

Growth characteristics of various melanoma xenografts treated with regional LPAM (90 mg/kg) and toxicity

Xenograft% Increase in tumor volume on day 30 (%, mean ± SE)Quintupling time (d, mean ± SE)Growth delay (d)Regression no. of ratsResponse CR/PR no. of rats% Maximal decrease in tumor size (%, mean ± SE)
DM440112.0 ± 66.950.1 ± 3.731.16/60/241.3 ± 12
DM443222.7 ± 64.748.0 ± 5.424.24/61/145.5 ± 13.1
DM366131.4 ± 65.846.2 ± 4.628.76/61/251.8 ± 11
DM6150.7 ± 52.748.2 ± 5.428.54/60/130.8 ± 6.2
DM738432.0 ± 24.423.2 ± 2.82.21/60/0−0.7 ± 7.2
  • Abbreviations: CR, complete response; PR, partial response.