Table 1.

Mean DR5 and YY1 protein expression in PC-3 cells

Hours of treatment
6121824
A. DR5
    Untreated4.8 ± 0.155.33 ± 0.216.07 ± 0.25.59 ± 0.24
    Vincristine (0.05 μg/mL)8.88 ± 0.49.14 ± 0.2212.14 ± 0.2512.24 ± 0.33
    P*0.020.020.020.019
    Untreated4.8 ± 0.155.33 ± 0.216.07 ± 0.25.59 ± 0.24
    VP-16 (5 μg/mL)10.25 ± 0.3113.16 ± 0.3112.18 ± 0.419.57 ± 0.21
    P*0.020.0210.020.023
    Untreated4.8 ± 0.155.33 ± 0.216.07 ± 0.25.59 ± 0.24
    CDDP (1 μg/mL)10.82 ± 0.4212.87 ± 0.4117.12 ± 1.3211.58 ± 0.55
    P*0.0210.0210.0180.02
    Untreated4.8 ± 0.155.33 ± 0.216.07 ± 0.25.59 ± 0.24
    ADR (1 μg/mL)10.19 ± 0.2513.89 ± 1.3115.2 ± 0.316.65 ± 0.2
    P*0.0210.0210.0230.017
B. YY1
    Untreated16.65 ± 0.4420.67 ± 0.8414.43 ± 0.8214.8 ± 0.41
    ADR (0.05 μg/mL)3.41 ± 0.84.3 ± 0.855.35 ± 0.626.9 ± 0.84
    P*<0.02<0.02<0.02<0.02
    Untreated16.65 ± 0.4420.67 ± 0.8414.43 ± 0.8214.8 ± 0.41
    CDDP (1 μg/mL)7.58 ± 0.426.84 ± 0.849.71 ± 0.838.01 ± 0.81
    P*0.0210.0210.0290.021
  • NOTE: Protein determination was assessed by Western blot analysis as described in Materials and Methods. Actin was used as internal control. Values represent the mean arbitrary units ± SEM derived by three independent experiments.

  • * Asymptomatic significance (two tailed), nonparametric Mann Whitney U test.