Table 1.

Aplidin sensitivity of a panel of low passaged sarcoma cell lines

Cell lineTumor originIC50 (nmol/L)
CNIO BCMPNST35.65 ± 6.11
SW672Liposarcoma33.14 ± 3.08
CNIO BJOsteosarcoma17.21 ± 4.2
A673Ewing sarcoma17.09 ± 5.69
CNIO BMHibernoma12.67 ± 5.33
CNIO BBMPNST8.22 ± 2.28
CNIO BPOsteosarcoma7.86 ± 3.61
CNIO BNFibrohistiocytoma6.44 ± 2.73
CNIO AYLeiomyosarcoma3.85 ± 0.37
CNIO AZFibrous tumor2.83 ± 0.73
CNIO AWLiposarcoma2.33 ± 0.66
CNIO AXLiposarcoma2.25 ± 1.53
SAOS-2Osteosarcoma1.93 ± 0.75
CNIO BFOsteosarcoma1.59 ± 0.09
CNIO CERhabdomyosarcoma1.21 ± 0.6
CNIO BIGIST1.0 ± 0.44
CNIO BGMyxoid fibrosarcoma0.92 ± 0.21
1455Liposarcoma0.89 ± 0.5
CNIO AALeiomyosarcoma0.27 ± 10.08
  • Abbreviations: MPNST, malignant peripheral nerve sheath tumor; GIST, gastrointestinal stromal tumor.