Table 2.

Pathologic scores of liver tissues from 3-mo-old Mdr2-KO and Mdr2+/− control mice either untreated or treated with tannic acid or selenomethionine

Treatment/genotypeDuctular proliferationPortal inflammationFibrosisMitotic activityCouncilman bodiesTotal score
Untreated
    Mdr2+/−0 ± 00 ± 00 ± 00.5 ± 0.40.3 ± 0.50.8 ± 0.5
    Mdr2-KO3.0 ± 02.7 ± 0.62.3 ± 0.60.7 ± 0.52.0 ± 1.110.7 ± 1.5
Tannic acid treated
    Mdr2+/−0 ± 00 ± 00 ± 01.0 ± 1.70 ± 01.0 ± 1.7
    Mdr2-KO3.0 ± 03.0 ± 03.0 ± 01.0 ± 1.70.7 ± 0.610.7 ± 2.1
Selenomethionine treated
    Mdr2+/−0 ± 00 ± 00 ± 00 ± 00.7 ± 0.60.7 ± 0.6
    Mdr2-KO2.7 ± 0.62.7 ± 0.61.3 ± 0.60.3 ± 0.61.3 ± 0.68.3 ± 1.2
  • NOTE: Pathologic scores were calculated as described in van Nieuwerk et al. (49).