Pathologic scores of liver tissues from 3-mo-old Mdr2-KO and Mdr2+/− control mice either untreated or treated with tannic acid or selenomethionine
| Treatment/genotype | Ductular proliferation | Portal inflammation | Fibrosis | Mitotic activity | Councilman bodies | Total score | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Untreated | ||||||||||||
| Mdr2+/− | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0.5 ± 0.4 | 0.3 ± 0.5 | 0.8 ± 0.5 | ||||||
| Mdr2-KO | 3.0 ± 0 | 2.7 ± 0.6 | 2.3 ± 0.6 | 0.7 ± 0.5 | 2.0 ± 1.1 | 10.7 ± 1.5 | ||||||
| Tannic acid treated | ||||||||||||
| Mdr2+/− | 0 ± 0 | 0 ± 0 | 0 ± 0 | 1.0 ± 1.7 | 0 ± 0 | 1.0 ± 1.7 | ||||||
| Mdr2-KO | 3.0 ± 0 | 3.0 ± 0 | 3.0 ± 0 | 1.0 ± 1.7 | 0.7 ± 0.6 | 10.7 ± 2.1 | ||||||
| Selenomethionine treated | ||||||||||||
| Mdr2+/− | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0.7 ± 0.6 | 0.7 ± 0.6 | ||||||
| Mdr2-KO | 2.7 ± 0.6 | 2.7 ± 0.6 | 1.3 ± 0.6 | 0.3 ± 0.6 | 1.3 ± 0.6 | 8.3 ± 1.2 | ||||||
NOTE: Pathologic scores were calculated as described in van Nieuwerk et al. (49).