Table 1.

Drug concentrations in plasma and tumor tissue

Animal no.Drug and dosage, mg/kg/dMaximum plasma levels*, μg/L (μmol/L)Tumor tissue levels*, ng/mg (approximately μmol/L)
1No drug treatment<0.5<0.2
2Cxb 306,950 (18.2)17.53 (0.046)
3Cxb 909,450 (24.8)44.03 (0.116)
4Cxb 15014,000 (36.8)61.23 (0.161)
5Cxb 18017,000 (44.6)94.78 (0.249)
6DMC 303,035 (7.6)8.27 (0.021)
7DMC 903,190 (8.0)14.44 (0.037)
8DMC 1509,500 (23.8)39.04 (0.099)
9DMC 18018,200 (45.5)110.42 (0.280)
  • Abbreviation: Cxb, celecoxib.

  • * Average of two measurements.

  • Detection limit in blood was ∼5 μg/L.

  • Detection limit in tumor tissue was ∼5 ng/mg.