Drug concentrations in plasma and tumor tissue
| Animal no. | Drug and dosage, mg/kg/d | Maximum plasma levels*, μg/L (μmol/L) | Tumor tissue levels*, ng/mg (approximately μmol/L) |
|---|---|---|---|
| 1 | No drug treatment | <0.5† | <0.2‡ |
| 2 | Cxb 30 | 6,950 (18.2) | 17.53 (0.046) |
| 3 | Cxb 90 | 9,450 (24.8) | 44.03 (0.116) |
| 4 | Cxb 150 | 14,000 (36.8) | 61.23 (0.161) |
| 5 | Cxb 180 | 17,000 (44.6) | 94.78 (0.249) |
| 6 | DMC 30 | 3,035 (7.6) | 8.27 (0.021) |
| 7 | DMC 90 | 3,190 (8.0) | 14.44 (0.037) |
| 8 | DMC 150 | 9,500 (23.8) | 39.04 (0.099) |
| 9 | DMC 180 | 18,200 (45.5) | 110.42 (0.280) |