Table 1.

Inhibitors of ERBB family receptors, signal transducers, and kinase proteins downstream of the growth factor receptors

Protein targetSmall-molecule inhibitorAntibody inhibitor
ERBB1AG1478, erlotinib, gefitinib, lapatinib, EKB-569, HKI272, ZD6474, AEE788, and canertinib (CI-1033)Cetuximab, panitumumab, matuzumab, and pertuzumab
ERBB2Lapatinib, EKB-569, HKI272, and canertinibHerceptin and trastuzumab
ERBB3Canertinib
H-RAS/K-RASFarnesyltransferase and geranylgeranyl transferase inhibitors and statins
PI3KLY294002, wortmannin, and PX-866
PDK-1OSU-03012
AKTSH-5, SH-6, and AKT15B, Perifosine
RAF-1/B-RAFSorafenib
MEK1/2/5PD98059, U0126, and SL327
MEK1/2PD184352 and AZD6244
  • Abbreviation: PDK-1, phosphoinositide-dependent kinase-1.