Table 3.

Effect of halofuginone, alone and in combination with chemotherapy, on collagen, αSMA, Cygb/STAP, and Par-4 in prostate cancer and Wilms' tumor xenografts

Protein	Treatment
Protein		Control	Halofuginone	Chemotherapy	Halofuginone + chemotherapy
Collagen (arbitrary units)
PC	0.85 ± 0.05^a	0.37 ± 0.04^b	0.80 ± 0.06^a	0.17 ± 0.04^b
WT	0.70 ± 0.05^a	0.35 ± 0.05^b	0.72 ± 0.04^a	0.23 ± 0.03^b
αSMA (arbitrary units)
PC	0.61 ± 0.04^a	0.24 ± 0.02^b	0.65 ± 0.05^a	0.15 ± 0.01^b
WT	0.54 ± 0.08^a	0.32 ± 0.04^b	0.51 ± 0.04^a	0.15 ± 0.03^b
Cygb/STAP (arbitrary units)
PC	0.92 ± 0.11^a	0.45 ± 0.04^b	0.89 ± 0.07^a	0.23 ± 0.01^b
WT	0.74 ± 0.11^a	0.33 ± 0.08^b	0.71 ± 0.08^a	0.21 ± 0.01^b
Par-4 (arbitrary units)
PC	0.03 ± 0.01^a	0.27 ± 0.06^b	0.29 ± 0.04^b	0.30 ± 0.04^b

NOTE: Image analysis using ImagePro software was done on at least five sections taken from different animals and the mean results were expressed as arbitrary units. In each line, means without a common superscript differ significantly (P < 0.05) from the control according to Duncan's multiple range test.
Abbreviations: PC, prostate cancer; WT, Wilms' tumor.