Table 3.

Effect of halofuginone, alone and in combination with chemotherapy, on collagen, αSMA, Cygb/STAP, and Par-4 in prostate cancer and Wilms' tumor xenografts

ProteinTreatment
ControlHalofuginoneChemotherapyHalofuginone + chemotherapy
Collagen (arbitrary units)
    PC0.85 ± 0.05a0.37 ± 0.04b0.80 ± 0.06a0.17 ± 0.04b
    WT0.70 ± 0.05a0.35 ± 0.05b0.72 ± 0.04a0.23 ± 0.03b
αSMA (arbitrary units)
    PC0.61 ± 0.04a0.24 ± 0.02b0.65 ± 0.05a0.15 ± 0.01b
    WT0.54 ± 0.08a0.32 ± 0.04b0.51 ± 0.04a0.15 ± 0.03b
Cygb/STAP (arbitrary units)
    PC0.92 ± 0.11a0.45 ± 0.04b0.89 ± 0.07a0.23 ± 0.01b
    WT0.74 ± 0.11a0.33 ± 0.08b0.71 ± 0.08a0.21 ± 0.01b
Par-4 (arbitrary units)
    PC0.03 ± 0.01a0.27 ± 0.06b0.29 ± 0.04b0.30 ± 0.04b
  • NOTE: Image analysis using ImagePro software was done on at least five sections taken from different animals and the mean results were expressed as arbitrary units. In each line, means without a common superscript differ significantly (P < 0.05) from the control according to Duncan's multiple range test.

  • Abbreviations: PC, prostate cancer; WT, Wilms' tumor.