Table 2.

Effect of halofuginone, alone and in combination with chemotherapy, on tumor development in Wilms' tumor xenografts

TreatmentDay 66
Day 72
Day 75
Day 84
Volume (mm3)
Control71 ± 32a330 ± 50a338 ± 107a686 ± 100a
Halofuginone44 ± 31a80 ± 50ab84 ± 50ab125 ± 20ab
Chemotherapy (low)26 ± 12a56 ± 29ab67 ± 20ab99 ± 20ab
Halofuginone + chemotherapy (low)17 ± 3.0a24 ± 8.4b24 ± 8.5b30 ± 11b
Chemotherapy (high)11 ± 1.7a16 ± 2.3b18 ± 2.7b17 ± 2.6b
  • NOTE: Chemotherapy was given at low doses of dactinomycin (0.525 mg/mL) once a week and vincristine (0.583 mg/mL) once every 3 wks or at high doses of dactinomycin (1.575 mg/mL) once a week and vincristine (1.75 mg/mL) once every 3 wks. During the experiments, tumor volume was determined with a caliper. The results are presented as mean ± SE of five to seven animals in each group. In each column, means without a common superscript differ significantly (P < 0.05) according to Duncan's multiple range test.