Table 1.

Effect of halofuginone, alone and in combination with docetaxel (Taxotere), on tumor development in prostate cancer xenografts

TreatmentDay 10
Day 21
Day 26
Day 30
Volume (mm)3Weight (g)
Control310 ± 60a450 ± 90a582 ± 111a1.56 ± 0.3a
Halofuginone126 ± 48a201 ± 97ab254 ± 95ab0.70 ± 0.2ab
Taxotere (6 mg/kg)247 ± 74a331 ± 97ab327 ± 89ab0.81 ± 0.2ab
Halofuginone + Taxotere (6 mg/kg)155 ± 51a173 ± 55b182 ± 63b0.46 ± 15b
Taxotere (12.5 mg/kg)226 ± 75a185 ± 50b186 ± 48b0.47 ± 10b
  • NOTE: During the experiments, tumor volume was determined with caliper and tumor weight was evaluated at the end of the experiment. The results are presented as mean ± SE of five to seven animals in each group. In each column, means without a common superscript differ significantly (P < 0.05) according to Duncan's multiple range test.