Table 2.

Combining 28 d of AZD2171 (6 mg/kg/d) treatment with fractionated radiotherapy

TreatmentRTV4 (d)DT (d)DT after drug removalNadir volume, mm3 (d)
Calu-6
    Vehicle11 ± 0.55 ± 0.2
    AZD2171*36 ± 217 ± 1
    IR32 ± 28 ± 0.5311 ± 18 (12)
    IR + AZD2171 sequential50 ± 4*NA7 ± 0.4191 ± 23 (20)
    IR + AZD2171 concomitant48 ± 3*NA7 ± 0.3161 ± 7 (17)
LoVo
    Vehicle12 ± 16 ± 0.7
    AZD2171*35 ± 316 ± 2
    IR31 ± 19 ± 0.5275 ± 36 (10)
    IR + AZD2171 sequential47 ± 2NA9 ± 1204 ± 36 (13)*
    IR + AZD2171 concomitant44 ± 1NA9 ± 0.5164 ± 34 (12)*
  • NOTE: Nadir volume, lowest recorded tumor volume after the initiation of treatment.

  • Abbreviations: IR, ionizing radiation; DT, tumor volume doubling time; NA, not applicable (insufficient tumor regrowth during treatment period with AZD2171 to allow an accurate determination of doubling time).

  • * P < 0.05 compared with radiation alone.

  • P < 0.001 compared with radiation alone, Mann-Whitney U test. Values shown are the mean ± SE.